Endocrine Journal Club

Intensive glucose control in DM1 and long term risk of impaired GFR

2011-11-16T14:48:00.000-08:00

Intensive Diabetes Therapy and GFR in Type 1 DiabetesThe DCCT/EDIC Research Group*NEJM Nov 12, 2011AbstractBACKGROUNDAn impaired glomerular filtration rate (GFR) leads to end-stage renal disease and increases the risks of cardiovascular disease and death. Persons with type 1 diabetes are at high risk for kidney disease, but there are no interventions that have been proved to prevent impairment of

Long-Term Persistence of Hormonal Adaptations to Weight Loss

2011-10-27T07:24:00.000-07:00

Priya Sumithran, M.B., B.S., Luke A. Prendergast, Ph.D., Elizabeth Delbridge, Ph.D., Katrina Purcell, B.Sc., Arthur Shulkes, Sc.D., Adamandia Kriketos, Ph.D., and Joseph Proietto, M.B., B.S., Ph.D.N Engl J Med 2011; 365:1597-1604October 27, 2011 BackgroundAfter weight loss, changes in the circulating levels of several peripheral hormones involved in the homeostatic regulation of body

Review - Recurrent/Persistent Primary Hyperparathyroidism

2011-10-25T16:52:00.000-07:00

R. Udelsman. J Clin Endocrinol Metab, October 2011, 96(10):2950 –2958Excellent review from JCEM here.Useful extracted quotes:Persistent 1°HPTH accounts for the vast majority of patients who require reexploration.The most common cause of persistent 1°HPTH is surgeon inexperience in locating and adequately excising a parathyroid adenoma. Although a subset of these retained glands will eventually be

Quote for the Day

2011-10-25T13:12:00.001-07:00

"The purpose of computing is insight; not numbers." -RW Hamming

Clinical Inertia as a Clinical Safeguard - JAMA 2011

2011-10-24T17:08:00.000-07:00

Article here.Seems to be the month for sensible articles about Medicine.

Conflicts of Interest Abound in Diabetes Guidelines Committees

2011-10-18T14:30:00.000-07:00

(from Medscape)Reed MillerOctober 12, 2011 (New York, New York) — About half the experts serving on the committees that wrote national clinical guidelines for diabetes and hyperlipidemia over the past decade had potential financial conflicts of interest (COI), and about 4% had conflicts that were not disclosed [1].Dr Jennifer Neuman (Mount Sinai School of Medicine, New York, NY) and colleagues

If you read nothing else this month, read this

2011-10-13T11:35:00.000-07:00

The New Language of Medicine - NEJM 2011Finally, someone is addressing the real problems in medicine right now. Everything we do should be based on clinical judgement. Now it's a dirty word. Down with flowcharts, guidelines, evidenced based non-sense, public health data miners, physician "extenders", doctor-nurses and bean counters! (And by the way down with electronic medical records until that

ACTH stim test in diagnosis of aldosterone producing adenoma

2011-10-12T11:25:00.000-07:00

Significane of ACTH Stimulation Test in the Diagnosis of an Aldosterone Producing AdenomaTakuhiro Sonomyam et. alAbstractContext: Adrenal venous sampling is the “gold standard” test in the diagnosis of an aldosterone-producing adenoma (APA) among patients with primary aldosteronism (PA) but is available only in specialized medical centers. Meanwhile, an APA is reported to be generally more

Abstract 1489: Mechanisms Underlying Cardioprotective Effects Of Glucagon-like Peptide-1 In Ischemia-reperfusion Injury

2011-10-04T13:12:00.000-07:00

This study discuss the mechanism of incretin benefit in the heart. This also is from the expert of incretin in the west side of the hemisphere, Daniel Drucker. This shows that the DPPIV blunts the benefit of GLP-1. Kiwon Ban ; Judith Hoefer ; Steffen S Bolz ; Daniel J Drucker ; Mansoor Husain

Effects of DPP-4 inhibition on cardiac metabolism and function in mice.

2011-10-04T12:20:00.000-07:00

Effects of DPP-4 inhibition on cardiac metabolism and function in mice.Lenski M, Kazakov A, Marx N, Böhm M, Laufs U.SourceKlinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, Homburg/Saar, Germany.AbstractType 2 diabetes is associated with an increased risk of cardiac complications. Inhibitors of dipeptidylpeptidase 4 (DPP

Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies.

2011-10-03T22:26:00.000-07:00

Click on title for pdf download... Should diabetes patients be on these new incretin drugs long term? Gastroenterology. 2011 Jul;141(1):150-6. Epub 2011 Feb 18. Abstract BACKGROUND & AIMS: Glucagon-like peptide-1-based therapy is gaining widespread use for type 2 diabetes, although there are concerns about risks for pancreatitis and pancreatic and thyroid cancers. There are also concerns

Thyroidal Effects of Metformin Treatment in Patients with PCOS

2011-09-27T15:30:00.001-07:00

(click the title above to get to the paper) Mario Rotondi et al. Clin Endocrinol. 2011;75(3):378–381 Objective Metformin is widely used for the treatment of type 2 diabetes. Growing evidence supports the beneficial effects of metformin also in patients with polycystic ovary syndrome (PCOS). It was recently reported that metformin has a TSH-lowering effect in hypothyroid patients with

Incretins and pancreatic cancer

2011-09-19T14:03:00.001-07:00

Log in or create a free account for complete access to everything MedPage Today has to offer! EASD: Debate Brings Incretin Risks to Forefront By Kristina Fiore, Staff Writer, MedPage Today Published:

Rising incidence of second cancers in patients with low-risk (T1N0) thyroid cancer who receive radioactive iodine therapy.

2011-09-17T09:44:00.001-07:00

The objective of this study was to evaluate patterns of RAI use and elevated risk of secondary primary malignancies (SPM) in patients with low-risk (T1N0) WDTC. The Surveillance, Epidemiology, and End Results (SEER) database was used to analyze trends in RAI use over time in the United States. To determine the excess risk of secondary primary malignancies (SPM) the standardized incidence

Clinical Relevance of Thyroglobulin Doubling Time in the Management of Patients with Differentiated Thyroid Cancer

2011-09-12T14:33:00.000-07:00

This current editorial of the study from Thyroid, Miyauchi et al. has some meat to it. It is in line with what we are doing in low risk thyroid cancer patients. Read it!! Andy Clinical Relevance of Thyroglobulin Doubling Time in the Management of Patients with Differentiated Thyroid Cancer To cite this article: Furio Pacini, Mona M. Sabra and R. Michael Tuttle. Thyroid. July 2011, 21(7): 691

too glucose centric

2010-10-14T13:54:00.001-07:00

http://www.medscape.com/viewarticle/726443?sssdmh=dm1.642655&src=journalnl&uac=122459DY -- Dr. Wei-An Andy LeeClinical EndocrinologistAssistant Professor of Clinical MedicineKeck School of MedicineUniversity of Southern California"This email message is confidential, intended only for the recipient(s) named above and may contain information this is privileged, exempt from disclosure under

Subclinical hypothyroidism and the risk of coronary heart disease and mortality.

2010-09-27T09:30:00.001-07:00

JAMA. 2010 Sep 22;304(12):1365-74.Subclinical hypothyroidism and the risk of coronary heart disease and mortality. Rodondi N, den Elzen WP, Bauer DC, Cappola AR, Razvi S, Walsh JP, Asvold BO, Iervasi G, Imaizumi M, Collet TH, Bremner A, Maisonneuve P, Sgarbi JA, Khaw KT, Vanderpump MP, Newman AB, Cornuz J, Franklyn JA, Westendorp RG, Vittinghoff E, Gussekloo J; Thyroid Studies Collaboration.

Weight loss through gastric banding: effects on TSH and thyroid hormones in obese subjects with normal thyroid function.

2010-09-04T10:20:00.001-07:00

Weight loss through gastric banding: effects on TSH and thyroid hormones in obese subjects with normal thyroid function.Dall'Asta C, Paganelli M, Morabito A, Vedani P, Barbieri M, Paolisso G, Folli F, Pontiroli AE. Cattedra di Medicina Interna, Dipartimento di Medicina, Chirurgia e Odontoiatria, Università degli Studi di Milano, Milan, Italy.AbstractStudies on thyroid function in obesity

Intensive Glucose Control and Cardiovascular Outcomes in Type 2 Diabetes (April 2010). Macisaac RJ, Jerums G.

2010-09-04T10:18:00.001-07:00

Heart Lung Circ. 2010 Aug 29. [Epub ahead of print] Intensive Glucose Control and Cardiovascular Outcomes in Type 2 Diabetes (April 2010).http://www.ncbi.nlm.nih.gov/pubmed/20807681Macisaac RJ, Jerums G. Endocrine Centre and Department of Medicine, Austin Health and University of Melbourne, Australia.AbstractNumerous observational studies have clearly shown a relationship between hyperglycaemia

sulfonureas are ok

2010-09-02T07:33:00.001-07:00

J Clin Endocrinol Metab. 2010 Aug 11. [Epub ahead of print] Impact of Type of Preadmission Sulfonylureas on Mortality and Cardiovascular Outcomes in Diabetic Patients with Acute Myocardial Infarction.Zeller M, Danchin N, Simon D, Vahanian A, Lorgis L, Cottin Y, Berland J, Gueret P, Wyart P, Deturck R, Tabone X, Machecourt J, Leclercq F, Drouet E, Mulak G, Bataille V, Cambou JP, Ferrieres J,

Hospital Monopolies Ruin MRI Bill as Sutter Gets Price It Wants

2010-08-23T11:31:00.000-07:00

This is a long article, but it is referring directly to my region and the problems that I have been involved in regarding the Sutter Medical Group buying out all of the local physicians.

Insulin Patch.

2010-08-20T13:59:00.001-07:00

FDA Approves Insulin Patch-Pen for Use With Insulin AspartYael Waknine July 27, 2010 — The US Food and Drug Administration (FDA) has granted 510(k) clearance to market an insulin patch-pen (Finesse; Calibra Medical, Inc) for up to 3 days' use with rapid-acting insulin aspart (NovoLog; Novo Nordisk, Inc). The bolus-only

Some Insulin-Producing Beta Cells May Persist In Long-Term Type 1 Diabetes Survivors.

2010-08-19T07:36:00.001-07:00

Some Insulin-Producing Beta Cells May Persist In Long-Term Type 1 Diabetes Survivors. HealthDay (8/18, Gordon) reported that, according to a study published online Aug. 10 in the journal Diabetes, "the insulin-producing beta cells destroyed by type 1 diabetes may actually be in a constant state of turnover, even in people who've had diabetes for decades." Researchers arrived at that

Angiotensin-receptor blockade and risk of cancer: meta-analysis of randomised controlled trials.

2010-08-17T08:13:00.000-07:00

Lancet Oncol. 2010 Jul;11(7):627-36. Epub 2010 Jun 11.Angiotensin-receptor blockade and risk of cancer: meta-analysis of randomised controlled trials. Sipahi I, Debanne SM, Rowland DY, Simon DI, Fang JC. Harrington-McLaughlin Heart & Vascular Institute, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. ilkesipahi@

big blue for insulin

2010-08-13T20:36:00.001-07:00

Impact of an Interactive Online Nursing Educational Module on Insulin Errors in Hospitalized Pediatric Patients Mary M. Sullivan, RN, DNP, ANP-BC, CDE1, Colette R. O'Brien, RN, MS, C-PNP, CDE2, Stephen E. Gitelman, MD2, Susan E. Shapiro, RN, PHD1 and Robert J. Rushakoff, MD3 +

Weight and Metabolic Outcomes After 2 Years on a Low-Carbohydrate Versus Low-Fat Diet

2010-08-12T13:02:00.001-07:00

Weight and Metabolic Outcomes After 2 Years on a Low-Carbohydrate Versus Low-Fat Diet A Randomized Trial Gary D. Foster, PhD; Holly R. Wyatt, MD; James O. Hill, PhD; Angela P. Makris, PhD, RD; Diane L. Rosenbaum, BA; Carrie Brill, BS;

Effectiveness of statins is called into question

2010-08-11T15:35:00.001-07:00

Effectiveness of statins is called into question The drugs clearly help patients who have already had a heart attack. But their use has skyrocketed in patients hoping to prevent a first heart attack. In those cases, the benefits are dubious. August 09, 2010|By Melissa Healy, Los Angeles Times FIND MORE STORIES ABOUT: Statins Ricardo DeAratanha /

Treatment of Type B Insulin Resistance: A Novel Approach to Reduce Insulin Receptor Autoantibodies

2010-08-09T11:53:00.001-07:00

Treatment of Type B Insulin Resistance: A Novel Approach to Reduce Insulin Receptor Autoantibodies R. Malek, A. Y. Chong, B. C. Lupsa, A. O. Lungu, E. K. Cochran, M. A. Soos, R. K. Semple, J. E. Balow and P. Gorden Clinical Endocrine Branch (R.M., A.Y.C., B.C.L., A.O.L., E.K.C., P.G.) and Kidney Diseases Branch (J.E.B.), National Institute of Diabetes and Digestive and Kidney

Low carb gets another boost.

2010-08-03T06:37:00.001-07:00

1. Foster GD, Wyatt HR, Hill JO, et al. Weight and Metabolic Outcomes After 2 Years on a Low-Carbohydrate Versus Low-Fat Diet. Annals of Internal Medicine. 2010;153(3):147 -157. Conclusion: Successful weight loss can be achieved with either a low-fat or low-carbohydrate diet when coupled with behavioral treatment. A low-carbohydrate diet is associated with favorable changes in cardiovascular

Like the new format of NEJM.

2010-07-29T08:07:00.001-07:00

Here is the endocrinology section organized for readinghttp://www.nejm.org/endocrinology-- Dr. Wei-An Andy LeeClinical Endocrinologist Assistant Professor of Clinical MedicineKeck School of MedicineUniversity of Southern California"This email message is confidential, intended only for the recipient(s) named above andmay contain information this is privileged, exempt from disclosure under

new look

2010-07-15T22:20:00.001-07:00

check out the new look-- Dr. Wei-An Andy LeeClinical EndocrinologistAssistant Professor of Clinical MedicineKeck School of MedicineUniversity of Southern California"This email message is confidential, intended only for the recipient(s) named above and may contain information this is privileged, exempt from disclosure under applicable law.If you are not the intended recipient, do not disclose or

ACCORD Endocrine statements

2010-07-15T07:44:00.001-07:00

"These studies do not advise against the treatment of hypertension in patients with diabetes; the controversy concerns the target level to which blood pressure should be reduced in these patients. The conclusions of the ACCORD BP study suggest that achieving a systolic blood pressure of 120 mm Hg compared to 140 mm Hg does not reduce the rate of major cardiovascular events. Furthermore, systolic

Webcast on androgens for women and men.

2010-07-15T07:41:00.001-07:00

http://www.endo-society.org/media/ENDO-07/webcasts/androgens_women.cfm-- Dr. Wei-An Andy LeeClinical Endocrinologist Assistant Professor of Clinical MedicineKeck School of MedicineUniversity of Southern California"This email message is confidential, intended only for the recipient(s) named above andmay contain information this is privileged, exempt from disclosure under applicable law. If you are

Postmenopausal Hormone Therapy: An Endocrine Society Scientific Statement

2010-07-15T06:25:00.000-07:00

Hot off the presses, a scientific statement by the Endocrine Society about the use of hormone replacement in Post-menopausal women. This may be the first statement to tackle the issue of HRT in women immediately after entering menopause. The authors also review data from the WHI and report "Data from the various Women's Health Initiative studies, which involved women of average age 63, cannot

Glargine, malignancy

2010-07-01T07:38:00.001-07:00

Diabetes Care. 2010 Jun 14. [Epub ahead of print]DOSES OF INSULIN AND ITS ANALOGUES AND CANCER OCCURRENCE IN INSULIN-TREATED TYPE 2 DIABETIC PATIENTS.Mannucci E, Monami M, Balzi D, Cresci B, Pala L, Melani C, Lamanna C, Bracali I, Bigiarini M, Barchielli A, Marchionni N, Rotella CM.Diabetes Agency, Careggi Teaching Hospital, Florence, Italy.AbstractAbstractObjective: Recent

Adverse Events Associated with Testosterone Administration

2010-06-30T15:21:00.000-07:00

Adverse Events Associated with Testosterone Administration Shehzad Basaria, M.D., Andrea D. Coviello, M.D., Thomas G. Travison, Ph.D., Thomas W. Storer, Ph.D., Wildon R. Farwell, M.D., M.P.H., Alan M. Jette, Ph.D., Richard Eder, B.A., Sharon Tennstedt, Ph.D., Jagadish Ulloor, Ph.D., Anqi Zhang, Ph.D., Karen Choong, M.D., Kishore M. Lakshman, M.D., Norman A. Mazer, M.D., Ph.D., Renee Miciek, M.S.,

PAS the celebrity

2010-06-24T13:12:00.001-07:00

http://today.msnbc.msn.com/id/26184891/vp/35121450#35124268http://thyroid.about.com/b/2010/01/28/today-show-thyroid-awareness.htm http://thyroid.about.com/b/2007/10/02/attention-thyroid-patients-hyperthyroidism-symptoms-are-like-being-in-love-says-usc-endocrinologist-peter-singer.htm -- Dr. Wei-An Andy LeeClinical EndocrinologistAssistant Professor of Clinical MedicineKeck School of

BPA and Metabolic Syndrome

2010-06-15T08:40:00.000-07:00

A recent study was just published revealing that there is no significant link between mice being exposed to BPA in the fetal and prenatal stage, and development of obesity as adults.ABSTRACT:Bisphenol-A (BPA) is an endocrine-disrupting chemical used in the production of plastic food and beverage containers, leading to ubiquitous low-dose human exposure. It has been suggested that exposure to even

EMR. Hidden costs?

2010-05-06T11:58:00.001-07:00

Here is a nice story of hidden costs of EMR.Read it here:http://www.boston.com/news/nation/articles/2010/05/04/for_some_doctors_national_computerized_medical_records_dont_pay/?page=full -- Dr. Wei-An Andy LeeClinical EndocrinologistAssistant Professor of Clinical MedicineKeck School of MedicineUniversity of Southern California"This email message is confidential, intended only for the recipient(s)

Get your billing stuff on!!

2010-05-05T17:20:00.001-07:00

got a pdf of codes for metabolic disease. check it out in good reader..... -- Dr. Wei-An Andy LeeClinical EndocrinologistAssistant Professor of Clinical MedicineKeck School of MedicineUniversity of Southern California"This email message is confidential, intended only for the recipient(s) named above and may contain information this is privileged, exempt from disclosure under applicable law.If

cholestyramine and Grave's

2010-05-05T17:19:00.001-07:00

this was a reference in uptodate. Hyperthyroidism and the use of cholestyramine. TI Treatment of hyperthyroidism with a combination of methimazole and cholestyramine. AU Mercado M; Mendoza-Zubieta V; Bautista-Osorio R; Espinoza-de los Monteros AL SO J Clin Endocrinol Metab 1996 Sep;81(9):3191-3. The entero-hepatic circulation of thyroid hormones is increased in thyrotoxic states. Based

Long Term Bisphosphonate Use

2010-05-04T12:42:00.002-07:00

This study by Nelson B. Watts and Dima L. Diab from University of Cincinnati is an excellent review of the pharmacodynamics and pharmacokinetics of bisphosphonates and the effect of their long term use. I thought what was striking about this particular article are the recommendations of a drug holiday. This is something many have discussed previously but has not be published significantly."

Diabetes on the Rise. Data from the CDC.

2010-05-04T12:42:00.001-07:00

Just some numbers to keep in mind for diabetes prevalence.Prevalence of diagnosed and undiagnosed diabetes in the United States, all ages, 2007Total: 23.6 million people or 7.8% of the population have diabetes. Diagnosed: 17.9 million peopleUndiagnosed: 5.7 million peoplePrevalence of diagnosed and undiagnosed diabetes among people aged 20 years or older,United States, 2007Age 20 years or older:

Androgen abuse in athletes

2010-05-04T06:07:00.000-07:00

Shehzad Basaria CLINICAL REVIEW:Androgen Abuse in Athletes: Detection and Consequences J Clin Endocrinol Metab 2010 95: 1533-1543I liked this article for several reasons:1. Interesting and timely topic. Not only as it relates to professional sports, but also office consultations from non-professional athletes who have gotten involved in performance

Let the ipad generation begin.

2010-05-01T17:51:00.001-07:00

Please upload at least one good review article and one study per week for this endocrine journal club.This will allow for goodreader download.I have put endocrine textbook pdf for this community. Andy

Sleep Deprivation Leads to Insulin Resistance

2010-04-07T06:21:00.000-07:00

A Single Night of Partial Sleep Deprivation Induces Insulin Resistance in Multiple Metabolic Pathways in Healthy Subjects Esther Donga*, Marieke van Dijk, J. Gert van Dijk, Nienke R. Biermasz, Gert-Jan Lammers, Klaas W. van Kralingen, Eleonara P. M. Corssmit, and Johannes A. RomijnThis study examined the effect of sleep deprivation on insulin resistance. The volunteers were allowed to

Fwd: Alert: Joint Statement on Radioactive Precautions Following I-131 Therapy

2010-03-31T07:28:00.000-07:00

About | Calendar | Membership | Journals & Publications | Contact Us March 31, 2010 Joint Statement on Radioactive Precautions Following Radioactive Iodine Therapy The American Thyroid Association (ATA), The Endocrine Society (TES), the Society of Nuclear Medicine (SNM), the American Association of Clinical Endocrinologists (AACE) Radioactive iodine (I-131)

Cats and hyperthyroidism

2010-03-24T13:44:00.001-07:00

Epidemiologic study of relationships between consumption of commercial canned food and risk of hyperthyroidism in cats Charlotte H. Edinboro, DVM, PhD J. Catharine Scott-Moncrieff, VetMB, MS, DACVIM Evan Janovitz, DVM, PhD, DACVP H. Leon Thacker, DVM, PhD, DACVP Larry T. Glickman, VMD, DrPH Departments of Veterinary Pathobiology, School of Veterinary Medicine, Purdue University, West

Let the last supper be the guide for food portions!

2010-03-23T12:50:00.000-07:00

Has even the Last Supper been supersized? The food in famous paintings of the meal has grown by biblical proportions over the last millennium, researchers report in a medical journal Tuesday. Using a computer, they compared the size of the food to the size of the heads in 52 paintings of Jesus Christ and his disciples at their final meal before his death.

Fructosamine and HBA1C

2010-03-09T08:35:00.001-08:00

http://www.healthyinfo.com/clinical/endo/dm/hga1c.test.shtmlhttp://www.clinicalcorrelations.org/?p=160 -- Dr. Wei-An Andy LeeClinical EndocrinologistAssistant Professor of Clinical MedicineKeck School of MedicineUniversity of Southern California"This email message is confidential, intended only for the recipient(s) named above and may contain information this is privileged, exempt from disclosure

Weighing Risks and Benefits of Liraglutide — The FDA's Review of a New Antidiabetic Therapy

2010-02-17T16:32:00.000-08:00

Weighing Risks and Benefits of Liraglutide — The FDA's Review of a New Antidiabetic TherapyPublished at www.nejm.org February 17, 2010 (10.1056/NEJMp1001578)Worthwhile read not only for the interesting potential link between this medication and medullary thyroid cancer, but also a look at what goes into the approval process for new diabetic medications.

The signaling of glp 1

2010-02-13T09:05:00.000-08:00

Here's a website I think you'll like: A role for the gut-to-brain GLP-1-dependent axis i... [Curr Opin Pharmacol. 2009] - PubMed result-- Sent from my Palm Prē

JCEM does insulin pump primer

2010-02-09T22:35:00.001-08:00

J Clin Endocrinol Metab. 2009 Jul;94(7):2232-8. Epub 2009 Apr 21.Clinical review: Realistic expectations and practical use of continuous glucose monitoring for the endocrinologist.Hirsch IB.University of Washington School of Medicine, Seattle, Washington 98105, USA. ihirsch@u.washington.eduCONTEXT: Real-time continuous glucose monitoring (CGM) has been available for type 1 diabetes for

Hypoglycemia post GB surgery new spin!!

2010-02-07T14:26:00.000-08:00

Not beta cells but intestinal route!!Here's a website I think you'll like: Reversible Hyperinsulinemic Hypoglycemia after Gas... [J Clin Endocrinol Metab. 2010] - PubMed result-- Sent from my Palm Prē

Possible Weight loss drug target...

2010-02-03T08:36:00.000-08:00

Fyn-Dependent Regulation of Energy Expenditure and Body Weight Is Mediated by Tyrosine Phosphorylation of LKB1Eijiro Yamada, Jeffrey E. Pessin, Irwin J. Kurland, Gary J. Schwartz, Claire C. BastieThis is an article with a significant amount of biochemistry describing the effects of inhibition of Fyn-kinase in mice on weight loss. Without adding to much details here is a summary:They

Geek stuff

2010-02-03T05:40:00.000-08:00

These technologies may someday make their way into medicine and EMR technology. In any case it's just cool stuff.Thin Film Turns any Surface Into a TouchscreenSpray-on liquid glass is about to revolutionize almost everything

Lose more weight with bigger breakfast?

2010-02-03T05:01:00.000-08:00

Interesting summary of a study presented at Endo Society Meeting by Dr. Daniela Jakubowicz. Also info about a book.Breakfast of Champions--and thin peopleCorned beef for breakfast

Reconstituted HDL?

2010-01-19T21:27:00.001-08:00

Reconstituted HDL: A Therapy for Atherosclerosis and Beyond Abstract Cardiovascular disease is the leading cause of death in developed countries. As low levels of the cardioprotective particle HDL are associated with cardiovascular disease, raising HDL levels may lead to positive outcomes. Reconstituted HDL (rHDL) therapy in humans has resulted in regression of atheroma volume and plaque

Great Podcast on the topic of Osteoporosis

2010-01-15T05:41:00.000-08:00

This is a great podcast to share with patients on the topic of osteoporosis by our very own Dr. Komal Patil-Sisodia...http://www.hoaghospital.org/information/Podcast.aspx

Update in Male Osteoporosis

2010-01-13T11:56:00.000-08:00

This is a great review article on everything new in male osteoporosis by Dr. Khosla. He does a great job of summarizing male osteoporosis by focusing on three main topics: epidemiology, pathogenesis, and management.Context: Osteoporosis in men is becoming an increasingly important public health problem. One in five men over the age of 50 yr will suffer an osteoporotic fracture during their

Tight glycemic control can kill

2009-12-31T13:07:00.000-08:00

Here's a website I think you'll like: Tight Glucose Control May Increase Mortality in Critically Ill Patients (mobile format)-- Sent from my Palm Prē

Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR)

2009-11-29T16:19:00.001-08:00

The 10-year prevalence of retinopathy was nearly identical among individuals with impaired fasting glucose as among those with overt diabetes at baseline in a longitudinal French study of 700 adults. The findings provide further evidence that calls into question the current definition of diabetes, which was based on glycemic thresholds for retinopathy and nephropathy derived from cross-sectional

The rationale for the diagnosis of diabetes in questions!

2009-11-29T16:02:00.001-08:00

Lancet. 2008 Mar 1;371(9614):736-43. Relation between fasting glucose and retinopathy for diagnosis of diabetes: three population-based cross-sectional studies. Wong TY, Liew G, Tapp RJ, Schmidt MI, Wang JJ, Mitchell P, Klein R, Klein BE, Zimmet P, Shaw J. Centre for Eye Research Australia, University of Melbourne, VIC, Australia. twong@unimelb.edu.au Erratum in: Lancet. 2008 May 31;371(9627):

Anemia as a marker. Just a marker!! NEJM, November 19, 2009

2009-11-23T10:58:00.001-08:00

A Trial of Darbepoetin Alfa in Type 2 Diabetes and Chronic Kidney Disease NEJM, November 19, 2009 click here to read more.... ABSTRACT Background Anemia is associated with an increased risk of cardiovascular and renal events among patients with type 2 diabetes and chronic kidney disease. Although darbepoetin alfa can effectively increase hemoglobin levels, its effect on clinical outcomes

Exercise Reverses Aging

2009-11-19T06:21:00.000-08:00

Went to a very interesting grand rounds where Dr. Nair discussed some of the research from his lab. The focus of the lab is to assess the effects of aging and whether it is reversible. They found that most proteins seem to have different isoforms and they have developed a new technique (a 2D gel) to differentiate these. Using labeling techniques they showed that these isoforms are age related

Does Size really Matter?

2009-11-17T11:09:00.000-08:00

Body Fat Distribution, Adipocyte Size, and Metabolic Characteristics of Nondiabetic Adults Manpreet S. Mundi, Maksym V. Karpyak, Christina Koutsari, Susanne B. Votruba, Peter C. O'Brien, and Michael D. Jensen* Mayo Clinic, Department of Endocrinology, Rochester, Minnesota 55905 * To whom correspondence should be addressed. E-mail: jensen@mayo.edu