jci.org/articles/view/64895#.UME2jdJg-AU.twitter … #jci
Dr. Mundi, Dr. Laidlaw, and Dr. Lee would like to welcome you the Endocrine Journal Club.
Showing posts with label MP111212. Show all posts
Showing posts with label MP111212. Show all posts
Thursday, December 6, 2012
[27] debunked the weight independent effect of RYGB?
Tuesday, December 4, 2012
[26] What is the proportion of GLP-1 receptors in various malignant and benign thyroid tissue types?
What is the proportion of GLP-1 receptors in malignant and benign
thyroid tissue?
#MP111212
[Gier, JCEM, 2012, GLP-1 R, 18%, 33%]
http://www.ncbi.nlm.nih.gov/pubmed/22031513
thyroid tissue?
#MP111212
[Gier, JCEM, 2012, GLP-1 R, 18%, 33%]
http://www.ncbi.nlm.nih.gov/pubmed/22031513
J Clin Endocrinol Metab. 2012 Jan;97(1):121-31. doi: 10.1210/jc.2011-2407. Epub 2011 Oct 26.
Glucagon like peptide-1 receptor expression in the human thyroid gland.
Source
Larry L. Hillblom Islet Research Center, David Geffen School of Medicine at the University of California, Los Angeles, 10833 Le Conte Avenue 72-228 CHS, Los Angeles, California 90095-6904, USA.
Abstract
BACKGROUND:
Glucagon like peptide-1 (GLP-1) mimetic therapy induces medullary thyroid neoplasia in rodents. We sought to establish whether C cells in human medullary thyroid carcinoma, C cell hyperplasia, and normal human thyroid express the GLP-1 receptor.
METHODS:
Thyroid tissue samples with medullary thyroid carcinoma (n = 12), C cell hyperplasia (n = 9), papillary thyroid carcinoma (n = 17), and normal human thyroid (n = 15) were evaluated by immunofluorescence for expression of calcitonin and GLP-1 receptors.
RESULTS:
Coincident immunoreactivity for calcitonin and GLP-1 receptor was consistently observed in both medullary thyroid carcinoma and C cell hyperplasia. GLP-1 receptor immunoreactivity was also detected in 18% of papillary thyroid carcinoma (three of 17 cases). Within normal human thyroid tissue, GLP-1 receptor immunoreactivity was found in five of 15 of the examined cases in about 35% of the total C cells assessed.
CONCLUSIONS:
In humans, neoplastic and hyperplastic lesions of thyroid C cells express the GLP-1 receptor. GLP-1 receptor expression is detected in 18% papillary thyroid carcinomas and in C cells in 33% of control thyroid lobes. The consequence of long-term pharmacologically increased GLP-1 signaling on these GLP-1 receptor-expressing cells in the thyroid gland in humans remains unknown, but appropriately powered prospective studies to exclude an increase in medullary or papillary carcinomas of the thyroid are warranted.
Sunday, December 2, 2012
[25] Statins good for cancer?
![]() 12/2/12 12:02 AM Statins good for cancer? #mp111212 [neilson,nejm, 12,statin, cellular proliferation, cancer related mortality] ncbi.nlm.nih.gov/m/pubmed/23134… |
Sent from my iPhone
Thursday, November 29, 2012
[24] What is the long term durability of gastric bypass surgery for treatment of DM2?
Long term durability of gastric bypass surgery for treatment of DM2?
#MP111212
[Arterburn, Obesity Surgery, 2012, RYGB, 35%, 8.3 years]
http://link.springer.com/article/10.1007/s11695-012-0802-1/fulltext.html
#MP111212
[Arterburn, Obesity Surgery, 2012, RYGB, 35%, 8.3 years]
http://link.springer.com/article/10.1007/s11695-012-0802-1/fulltext.html
Wednesday, November 28, 2012
[23] The doctor said I was Obese.
[Post,Archives of Int Med, 11, Physician, NHNE survey, Perception]
#MP111212
Background Physician counseling is effective in promoting healthy behavior. We evaluated whether patient reports of physician acknowledgment of overweight patients' weight status are associated with the patients' perceptions of their own weight and desire to lose weight.
Methods We analyzed the 2005-2008 National Health and Nutrition Examination Survey data on adults aged 20 to 64 years with a body mass index (BMI) of at least 25.0 (calculated as weight in kilograms divided by height in meters squared). Logistic regressions were computed to evaluate the impact of reports of physician acknowledgment of patients' weight status on patients' perceptions of their weight, desire to weigh less, and attempts to lose weight.
Results In logistic regressions controlling for relevant confounding variables, participants with a BMI of 25 or greater (odds ratio [OR], 6.11; 95% confidence interval [CI], 4.38-8.53) and those with a BMI of 30 or greater (OR, 7.58; 95% CI, 5.83-9.84) both had an increased likelihood to perceive themselves as overweight if they were told by their physician that they were overweight. Similarly, participants with a BMI of 25 or greater (OR, 2.51; 95% CI, 2.15-2.94) and those with a BMI of 30 or greater (OR, 2.24; 95% CI, 1.74-2.88) had an increased likelihood to have attempted to lose weight in the previous 12 months if they had reported being told they were overweight. However, only 45.2% of individuals with a BMI of 25 or greater and 66.4% of those with a BMI of 30 or greater reported being told by a physician that they were overweight.
Conclusion Among patients who were overweight or obese, patient reports of being told by a physician that they were overweight were associated with more realistic perceptions of the patients' own weight, desire to lose weight, and recent attempts to lose weight.
[22] Should obesity be considered a brain disorder?
Should obesity be considered a brain disorder? #MP111212
[Volkow, AM J Psychiatry, 2007, obesity, addiction, hypothalamus]
http://ajp.psychiatryonline.org/article.aspx?articleID=98310
[Volkow, AM J Psychiatry, 2007, obesity, addiction, hypothalamus]
http://ajp.psychiatryonline.org/article.aspx?articleID=98310
Tuesday, November 27, 2012
[21] What is the impact of high fructose corn syrup on DM prevelance?
Impact of high fructose corn syrup on DM prevelance? #MP111212
[Goran, Global Public Health, 2012, high fructose corn syrup, diabetes,
20%]
http://graphics8.nytimes.com/packages/pdf/business/20121127_SUGAR/HFCSpaper.pdf
[Goran, Global Public Health, 2012, high fructose corn syrup, diabetes,
20%]
http://graphics8.nytimes.com/packages/pdf/business/20121127_SUGAR/HFCSpaper.pdf
Sunday, November 25, 2012
[20] 20th article and 200 yrs nejm
![]() 11/25/12 11:15 PM #mp111212 History of dm [polonsky, nejm, 12, 1500, aretaeus, 1812] 20th article milestone!! nejm.org/doi/full/10.10… Unfortunately, the improvement in outcomes for individual patients with diabetes has not resulted in similar improvements from the public health perspective. The worldwide prevalence of diabetes has continued to increase dramatically. The difficulty in applying the principles of diabetes care from the individual patient to the population reflects the unique challenges of implementing research findings and effecting behavioral change. ![]()
|
ddiabetes
eepi
Saturday, November 24, 2012
[19] Resistant Hypercalcemia
Resistant hypercalcemia #MP111212
[Varughese, 2011, Endocrine Reviews, RANK-L, hyperparathyroidism, parathyromatosis] http://m.edrv.endojournals.org/cgi/content/meeting_abstract/32/03_MeetingAbstracts/P3-91
This issue came up with a hospital consult recently. 76 yo female with primary hyperparathyroidism, CHF with EF 20%, Cr 1.8, calcium 12.3. Intolerant to sensipar. Question was posed of IV bisphosphonates vs denosumab for acute therapy.
[18] Summary of long term benefits of bariatric surgery
![]() 11/24/12 2:36 PM Best study showing weight loss benefits of bariatric sx? [Sjostrom, J Int Med, 12, SOS, mi, cancer] #mp111212 ncbi.nlm.nih.gov/m/pubmed/23163… |
Sent from my iPhone
[17] PCOS: Relationship of hyperandrogensim and hepatic steatosis
PCOS: Relat. of hyperandrogensim and hepatic steatosis #MP111212 [Jones,
JCEM, 2012, PCOS, hepatic steatosis, hyperandrogenism]
http://www.ncbi.nlm.nih.gov/pubmed/22837189
JCEM, 2012, PCOS, hepatic steatosis, hyperandrogenism]
http://www.ncbi.nlm.nih.gov/pubmed/22837189
Thursday, November 22, 2012
[16] M2 metabolite for glargine.
![]() 11/22/12 10:16 AM Lantus kinetics [Bolli,DiabetesCare,12,glargine,M2,metabolic effect] #mp111212 m.care.diabetesjournals.org/content/35/12/… |
#ddiabetes
#llantus
Sent from my iPhone
Sent from my iPhone
[15] Presentations of hypophysitis
Presentations of hypophysitis #MP111212 [Cheung, JCEM, 2001, idiopathic,
4, diffuse homogenous mass]
http://jcem.endojournals.org/content/86/3/1048.full.pdf
4, diffuse homogenous mass]
http://jcem.endojournals.org/content/86/3/1048.full.pdf
Wednesday, November 21, 2012
[14] Tg doubling time for papillary thyroid cancer patients
DTC prognosis [Miyauchi,thyroid,2011,Tg-DT,cause specific survival,multivariate analysis] online.liebertpub.com/doi/abs/10.108… #MP111212
[13] Subclinical Hypothyroidism and CVD risks
Old, tired, High TSH. Don't be so quick to pull the trigger on LT4. [Hyland,JCEM,12,subcHypo,20,CVD] ncbi.nlm.nih.gov/pubmed/23162099 #MP111212
[12] How do comorbidities effect mortality in hyperthyroidism?
How do comorbidities effect mortality in hyperthyroidism? #MP111212
[Brandt, JCEM, 2012, hyperthyroid, 21%, Charlson Score]
http://www.ncbi.nlm.nih.gov/pubmed/22930783
[Brandt, JCEM, 2012, hyperthyroid, 21%, Charlson Score]
http://www.ncbi.nlm.nih.gov/pubmed/22930783
[11] Animal Modeling of food addiction
Animal modeling of food addiction #MP111212 [de Jong, Obesity Facts, 2012, addiction, DSM IV criteria, D2 receptor]
http://www.ncbi.nlm.nih.gov/pubmed/22647301
Monday, November 19, 2012
[10] Mortality risk in non-hypertensive renal disease
Mortality risk in non-hypertensive renal disease #MP111212
[Mahmood,Lancet,2012,Mortality,eGFR,hypertension]
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(12)61272-0/abstract
[Mahmood,Lancet,2012,Mortality,eGFR,hypertension]
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(12)61272-0/abstract
Sunday, November 18, 2012
[9] Finest paper on Medical Statistics
Finest paper on medical statistics #mp111212
[Goodman,ArchIntMed,1999,Pvalue, inferential reasoning, hypoth. testing]
http://www.ncbi.nlm.nih.gov/m/pubmed/10383371/ …
[Goodman,ArchIntMed,1999,Pvalue, inferential reasoning, hypoth. testing]
http://www.ncbi.nlm.nih.gov/m/pubmed/10383371/ …
Saturday, November 17, 2012
[8] Femur strength vs bmd
![]() 11/17/12 1:47 PM #MP111212 Femur strength vs BMD/ethnicity for predicting fracture:[Ishii,JCEM,2012,strength indices,fracture,ethnicity] ncbi.nlm.nih.gov/pubmed/22865903 |
Sent from my iPhone
Subscribe to:
Posts (Atom)