Extreme biochem alert!!!
Just came back from recent fellows journal club and we discussed the discovery of a novel apolipoprotein V. I just wanted to add this to our Journal club because it may have some drug target implications.
Apolipoprotein V was discovered about six years ago and it appears that apoA-V may lead to increased plasma TG hydrolysis or mediate cellular uptake of remnant particles. It's over-expression leads to reduced levels of triglycerides.
It is still a novel apolipoprotein and its various isoforms have not been fully studied.
Click here for a good review article on the topic (if you have run out of Ambien).