From the VADT trial, it appears that there can be harm from intense glucose control. They looked at the benefit in relationship to duration of type 2 diabetes.
- "Duration was a significant predictor of the primary end point and showed a highly significant interaction with the treatment effect in the intensive-treatment group, suggesting that intensive treatment might be protective during the first decade of diabetes but that late intensive treatment in the fashion used in the VADT might be harmful. "
- "The CAC score was independent of standard cardiovascular risk factors and was an even stronger risk factor than having a prior event. Furthermore, Reaven showed evidence that the effect of the treatment assignment was modified by the baseline CAC score: the participants with a baseline CAC score <100>100. "