Incretin analogs have been a very powerful tool in the management of type 2 diabetes. Despite it's rapid acceptance and pervasive use, we have very limited understanding of any pathology that may arise from the dysregulation of this system.
One described phenomenon has been postprandial hypoglycemia after gastric bypass. Could the hypoglycemia that had been termed dumping syndrome be from the dysregulation or overstimation of this system?
An article in JCEM by Palladino tries to address this issue. He evaluated patients with fundoplication for an abnormal incretin response.
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