Monday, February 2, 2009
Erythromycin Antagonizes the Deceleration of Gastric Emptying by Glucagon-Like Peptide 1 and Unmasks Its Insulinotropic Effect in Healthy Subjects
In this study Nauk reveals some interesting things:
1. the predominant GLP-1 effect in the lowering of blood sugar comes from the lowering of GI motility and not the stimulation of insulin.
2. GLP-1 physiologically doesn't cause an increase in insulin. Rather, since it has such a strong effect of reducing GI motility, it actually lowers the postprandial insulin level.