Monday, February 2, 2009

Can GLP-1 really be classified as an incretin?

Erythromycin Antagonizes the Deceleration of Gastric Emptying by Glucagon-Like Peptide 1 and Unmasks Its Insulinotropic Effect in Healthy Subjects

In this study Nauk reveals some interesting things:
1. the predominant GLP-1 effect in the lowering of blood sugar comes from the lowering of GI motility and not the stimulation of insulin.
2. GLP-1 physiologically doesn't cause an increase in insulin. Rather, since it has such a strong effect of reducing GI motility, it actually lowers the postprandial insulin level.

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