Fyn-Dependent Regulation of Energy Expenditure and Body Weight Is Mediated by Tyrosine Phosphorylation of LKB1Eijiro Yamada, Jeffrey E. Pessin, Irwin J. Kurland, Gary J. Schwartz, Claire C. Bastie
This is an article with a significant amount of biochemistry describing the effects of inhibition of Fyn-kinase in mice on weight loss. Without adding to much details here is a summary:
They recently reported that conventional Fyn knockout mice displayed increased energy expenditure and fatty acid oxida- tion due to increased activation of adipose tissue and skeletal muscle AMPK activity, resulting in reduced adipose tissue mass and enhanced insulin sensitivity.
This group then used an Fyn-kinase inhibitor and noted that the mice given the drug had lower R/Q indicating increased fatty acid utilization as well as higher oxygen consumption.
The SU6656-treated animals also dis- played decreased body weight 12 hr after the injection and the total weight loss was 40% greater than that of the vehicle-treated group.